AlchemY of Аpogee [ Part I: Quality of Life ]
pages 64-65
Which are the biomarkers of genotoxic stress?
Table 15: Exemplary markers of genotoxic stress caused by toxic metabolites of oxidative processes due to some of our daily activities and habits, physiological functions or conditions
Activated antioxidant protection and natural sources of
the necessary antioxidants in the body.
Activity / status |
Signal of disturbance |
||
Intensive sport trainings: |
muscle fever, fatigue, cramps |
||
Oxidative process |
Antioxidant protection |
||
activating free radical |
Biochemical
/ |
Antioxidant |
Source |
· malone dialdehyde,, · superoxide, · peroxy-nitrite |
· protein breakdown, · fat peroxidation, ·
deposition of toxins around muscle tissue and tendons |
· glutathione, · uric acid, · superoxide dismutase, · magnesium |
· biosynthesis in the body, · natural anti-oxidant protection, · mineral water, cheese, tomatoes
|
Work with computer: |
impaired vision, dry skin and hair |
||
Oxidative process |
Antioxidant protection |
||
activating free radical |
Biochemical
/ |
Antioxidant |
Source |
· hydroxyl radical, · hydrogen peroxide, · superoxide, · positive ions |
· radiolysis, · breakdown of water molecules in the skin and hair, ·
dehydration |
· glutathione, · selenium, · water, · electrolytes, · Vitamin C, · vitamin E, · polyphenols
|
· natural biosynthesis, · complete nutrition with import of enough water, minerals, fruits and vegetables
|
Sunbathing, Solarium: |
burning, redness of the skin |
||
Oxidative process |
Antioxidant protection |
||
activating free radical |
Biochemical
/ |
Antioxidant |
Source |
· hydroxyl radical |
· lipid peroxidation, · protein breakdown, ·
DNA damage in epithelial cells |
· melatonin, · superoxide dismutase, · catalase, · peroxidase, · vitamins A, E. |
· biosynthesis in the body, · natural antioxidant protection, · carotenoids (carrots, olive oil, spinach)
|
Activity / status |
Signal of disturbance |
||
Digestion:: |
heartburn, bloating, upset stomach |
||
Oxidative process |
Antioxidant protection |
||
activating free radical |
Biochemical
/ |
Antioxidant |
Source |
· hydroxyl radical, · hydrogen peroxide, · superoxide |
· increase or decrease of pH in the gastrointestinal tract, · breakdown of important proteins and DNA in the tissues and organs involved in the entero-hepatic cycle (p.109,128) |
· superoxide dismutase, · catalase · peroxidase, · coenzyme Q10, · Vitamin C
|
· biosynthesis in the body, · natural antioxidant protection, · lettuce, dill, parsley |
Smoking:: |
extrasystoles, shortness of breath |
||
Oxidative process |
Antioxidant protection |
||
activating free radical |
Biochemical
/ |
Antioxidant |
Source |
· peroxynitrite, · benzo-a-pyrene |
· lipid peroxidation of the airways and cell walls in the lungs |
· superoxide dismutase, · catalase, · peroxidase, · Vitamin C
|
· biosynthesis in the body, · natural antioxidant protection, · citrus fruits |
Illness: |
fatigue, loss of appetite, constipation |
||
Oxidative process |
Antioxidant protection |
||
activating free radical |
Biochemical
/ |
Antioxidant |
Source |
· hydroxyl radical,
·
toxic xenobiotics |
· inflammation,
· increased liver toxicity and renal stagnation |
· superoxide dismutase, · catalase, · peroxidase, · Vitamin C
|
· biosynthesis in the body, · natural antioxidant protection, · citrus fruits |
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